Polyamines have several nitrogen atoms in the molecules. It is known that polyamines are biologically active molecules, which are involved in many biological phenomena. In this study, we will synthesize structurally new polyamines through the development of new catalytic reactions and modular synthesis.

The ammonium skeleton, which has a cation charge on the nitrogen atom, is included in many important molecules, such as bioactive molecules, surfactants, and organocatalysts due to its unique physical properties. However, there are few methods for synthesizing ammonium compounds, and the chemical space of ammonium compounds has not been fully exploited. In our laboratory, we develop an editiing method of ammonium skeletons and pursue new science pioneered by ammonium molecules.

We are leading the discovery of new bioactive molecules with a chemical library that is constructed through reaction development. Unlike natural product libraries, reaction products have a relatively simple structure. As the reactions have developed by us, a structure-activity relationship (SAR) study can be easily performed. Our laboratory has a large number of polyamines and ammonium salts, which can be provided as collaborative research. New biological activities have been already found in the reaction products.

We will verify the usefulness of this new focused library as a reaction development-based chemical library, which is different from natural product libraries and diversity-oriented synthesis libraries.